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      Enhance The Liver
          and Gallbladder
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ENHANCE THE LIVER AND GALLBLADDER

The purpose of his formula is to promote optimal function of the liver and gallbladder and to provide the intestinal mucosa with the energy substance it best utilizes, butyrate. Butyrate is a short chain fatty acid that is manufactured by healthy intestinal bacteria. It is the major energy source provided to the cells of the intestinal mucosa and aids these cells in the elimination of toxins. In this later function butyrate has been shown to decrease the tendency for intestinal cells to become cancerous. It also inhibits metastasis of cancer from the colon to the liver. The mechanism of action in butyrate’s ability to achieve these beneficial results is well understood and a few extrapolations can be drawn. Richie Shoemaker M.D. discovered, in his treatment of people with estuary syndrome, that many symptoms of this condition improved with the prescription drug cholestyramine. This drug binds bile acids and therefore the toxins they are carrying which lead to the conclusion that the toxins of pathogenic organisms can be found in the liver and are shunted to the intestinal tract via the bile. It is known that Bb can inhabit the intestinal lining in animals and likely humans as well. The toxins produced by Bb, like most chemicals that end up in the intestines, can have a direct negative affect on the cells of the intestines as well as the liver once they are absorbed by the blood and transported there. If the liver is unable to handle these toxins or becomes overwhelmed, these substances can negatively affect other tissues, those of the nervous system being the most commonly affected in a person with Lyme disease. It seems likely that butyrate, and other protective substances such as glutathione (see Enhance Glutathione), would be of benefit in helping the cells of the intestine and the liver break these toxins down into less harmful chemicals thereby limiting the overall impact on the nervous system.

The liver does the hard work in dealing with most of the chemicals in our bodies. It is especially burdened with toxins, neurological and others, and the debris of dead organisms during any chronic disease that has a pathogenic basis. It is very important improve and maintain optimal liver function in the treatment of Lyme disease. This formula has been designed to gently enhance the function of hepatocytes, improve the livers ability to detoxify the blood, improve the flow of bile. It can also help liver cells to heal as well as protect them from the damage that can occur during Lyme disease.

FORMULA INGREDIENTS
amount per capsule

• Oregon grape root 100 mg

• Milk thistle seed extract
(80% silymarin) 100 mg

• Qing pi 75 mg

• Dandelion root 125 mg

• Butyrate 161 mg

Most of the herbs in this formula are common western herbs that have been use in the treatment of liver disorders for centuries and need no rational for their incorporation in this formula. Butyrate has been discussed. Qing pi is the rind of green tangerine and has been utilized in Chinese herbal formulas that target the gallbladder and liver. It also activates liver Qi and warms the middle and lower burners (abdomen).

References;

Zajkowska JM, Hermanowska-Szpakowicz T.
[New aspects of the pathogenesis of lyme disease]
[Article in Polish]
1: Przegl Epidemiol. 2002;56 Suppl 1:57-67.

W. D. Leach, Adrian Lee and R. P. Stubbs
Localization of Bacteria in the Gastrointestinal Tract: a Possible Explanation of Intestinal Spirochaetosis; Infect Immun. 1973 June; 7(6): 961-972

Lee A. Normal flora of animal intestinal surfaces. In: Bitten G, Marshall KC, eds. Adsorption of microorganisms to surfaces. New York: Wiley & Sons, 1980:145–73.

J¸rgen Schrezenmeir and Michael de Vrese, Probiotics, prebiotics, and synbiotics—approaching a definition; American Journal of Clinical Nutrition, Vol. 73, No. 2, 361S-364s, February 2001

Roediger, W. Babidge W. Human colonocyte detoxification; GUT 1997; 41: 731-734 (Dec)

Kripke, SA. Fox AD, et al. Stimulation of intestinal mucosal growth with intracolonic infusion of short-chain fatty acids; J of Parenteral and Enteral Nutrition, Vol 13, Issue 2, 109-116

Ferrante, R.J. et al. Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington’s Disease in Mice; J of Neuroscience, Oct. 15, 2003; 23(28): 9418-9427

Uzma Shah, Walker W.A. Adverse Host Responses to Bacterial Toxins in Human Infants; J of Nut. 2000;130:420S-425S

Holmes, Peter; The Traditional Chinese Medicine Materia Medica Clinical Reference and Study Guide pg. 232-233